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August 2015

Volume 2 Issue 2

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Research Article
Changes In Heart Rate and Short Term Heart Rate Variability with Respect to the Circadian Pattern In Beta-Adrenoceptor 1, 2, and 3 Knockout Mice
Manuela Schloesser #, Alexander Ghanem #, Klaus Tiemann, Georg Nickenig, Joerg O. Schwab*

Heart rate variability (HRV) is used as a non-invasive method to analyse autonomic nervous system (ANS) activity and to asses the balance of sympatho-vagal activity on the heart. Decreased HRV is associated with an increased risk of ventricular arrhythmias and has been shown to constitute an independent prognostic factor for mortality in patients after acute myocardial infarction. HRV is affected by a complex interaction of the components of the ANS; the sympathetic nervous system causes an increase, the parasympathetic nervous system a decrease of the HRV.                                                                                                

                                                                                                                                                                                                                                           Download PDF  Full text___________________________________________________________________________________________

Review Article
State of the Art: Transcatheter Aortic Valve Replacement

Luca Testa*, Mauro Agnifili, Francesco Bedogni

Transcatheter aortic valve replacement determined a paradigm shift in the treatment of elderly patientswith severe symptomatic aortic stenosis at high or prohibitive risk for traditional surgical aortic valve replacement. Different prostheses are nowadays available for implantation via retrograde transfemoral, retrograde subclavian, transaortic or an antegrade transapical approach. Along with an increased experience and a growing body of literature the inherent procedural risks steadily decreased yet with the first generation of prostheses.                                      

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Short Article
The Heart Doesn’t Look Down: Cardiology and Cancer

Salvatore Patanè*

Nowadays, there is a need for a turning point in Cardio-oncology and both cardiologists and oncologists can contribute to a big step forward. Research identified novel therapeutic targets in cancer: Human ether-a-go-go-related gene K(+) channels (HERGs), Epidermal growth factor receptors (EGFRs), Vascular endothelial growth factor receptors (VEGFs) [5-11,12]. Related  therapies have been developed and cardiologists have been called in heart defense against their cardiotoxicity.

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